According to E! Online The Wonderful Maladys is a story "about three dysfunctional (are there any other kind in TV Land?) adult siblings living in New York and struggling to deal with the loss of their parents years ago."

Welcome back Gellar, TV hasn't been the same without you.

So Joss Whedon, genius behind Buffy, Angel, Firefly and the upcoming Dollhouse. had an idea that he thought would be fun to do.  He called his brothers and his friends Nate Fillion and Neil Patrick Harris (Doogie Howser, M.D, How I Met Your Mother)  and talked them into doing this short project called "Dr. Horrible's Sing Along Blog"

From Sci-Fi.com : "Whedon (Buffy the Vampire Slayer) wrote the musical series during last year's Writers' Strike. Co-writers for the Internet feature are Whedon's brothers, Zack and Jed, and Jed's fiancee, Maurissa Tancharoen. The story centers on a low-rent supervillain (Neil Patrick Harris), the hero who keeps beating him up (Nathan Fillion) and the cute girl from the laundromat he's too shy to talk to (Felicia Day). READ MORE